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Identical Twins Reveal Surprising Results After 20 Years of Botox Versus Natural Aging

One twin embraced Botox regularly, while the other chose a natural approach.

A pair of identical twins has shared fascinating insights after nearly two decades of choosing drastically different paths for their skincare routines. One twin underwent consistent Botox treatments, while the other opted for a more natural lifestyle.

The initial study, led by author William J. Binder, was published in 2006. It followed identical twin sisters, then aged 38, over 13 years. One twin received Botox injections in her forehead and glabellar region (between the eyebrows) two to three times annually.

In contrast, her sister only tried Botox twice—once in 1999 and again in 2003. Binder revisited the twins in 2012 to further analyze the long-term effects as they reached 44 years of age.

Botox works to relax the muscles in the face.

How Does Botox Work?

Botulinum toxin, commonly known as Botox, is injected to block nerve signals that cause muscle contractions.

The treatment temporarily paralyzes targeted muscles, relaxing facial muscles responsible for wrinkles like forehead lines, crow’s feet, and frown lines. Botox can also address neck spasms, excessive sweating, and migraines.

Twin 1 (left) had more noticeable wrinkles after 13 years with minimal Botox (American Society for Dermatologic Surgery)

Visible Differences After 13 Years

Binder’s study documented before-and-after images of the twins, showing the results of their differing choices.

By 2006, Twin 2 had received at least 26 Botox treatments since starting at age 21. Her skin appeared smoother with shallower forehead wrinkles. On the other hand, Twin 1, who only tried Botox twice, displayed deeper lines on her forehead and noticeable crow’s feet when she smiled.

Lines were more evident around Twin 1’s (left) eyes (American Society for Dermatologic Surgery)

Changes After 19 Years

The follow-up study nearly two decades later revealed even greater contrasts. At age 44, Twin 2’s wrinkles around her eyes and mouth were less pronounced than her sister’s.

Meanwhile, Twin 1’s jawline appeared fuller, but it remains unclear whether Botox played any role in this change.

Twin 1 (right) appeared to have a fuller face and jaw after 19 years with minimal Botox (American Society for Dermatologic Surgery).

Other Lifestyle Factors

While Botox usage was the major difference, the twins also lived in distinct environments. Twin 1 resided in Munich, Germany, while Twin 2 lived in Los Angeles, California.

Despite their locations, both led active outdoor lifestyles, worked indoors, and used daily sunblock. Neither smoked nor underwent other skin-tightening procedures like lasers or light therapy.

The study emphasized: “Consistent long-term treatment with onabotulinumtoxinA [Botox] seems to be the only major difference in the lives of these twins.”

Study Findings

Binder concluded that regular Botox use might prevent imprinted lines by relaxing muscles and subtly altering behaviors.

“With long-term treatment, patients may adjust to reduced muscle contraction, eventually ‘learning’ to avoid excessive movement,” Binder explained.

He further noted that relieving pressure from constant muscle tension might promote dermal remodeling over time.

Written by AB

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